Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Swanson, Thomas (2011). Effect of adolescent olanzapine administration on dendritic branching in the hippocampal circuit. (Mentor: A. Bailey)
Anti-psychotic drugs are frequently prescribed to adolescents. The long-term treatment effects of these drugs are poorly understood and may be particularly dangerous in relation to the undeveloped nervous system. We investigated the effect of the atypical anti-psychotic drug olanzapine on the developing adolescent hippocampal formation in orally-treated male Long-Evans rats. Cells from both the hippocampus CA3 and dorsal dentate gyrus of each brain were digitally reconstructed and analyzed for changes in dendritic branching length and node prevalence. There were no differences in node prevalence or dendritic branch for both apical and basal portions of hippocampus CA3 neurons. No difference was observed in node prevalence in dentate gyrus granule cells. Olanzapine-treated animals had significantly greater dendritic branching length in the dentate gyrus than water-vehicle controls. We purpose the observed changes in the dentate gyrus and subsequent hippocampal circuitry provide a neuroanatomical explanation for previously observed deficits in spatial memory and concentration ability in rats treated with olanzapine during adolescence.