Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Jones, Shelby (2012). Cognitive and behavioral impairments evaluated in the neonatal ventral hippocampus lesion rat model of schizophrenia. (Mentor: A.M. Brady)
The neonatal ventral hippocampus lesion is a neurodevelopmental model of schizophrenia that utilizes the disruption of specific anatomical pathways that may be directly related to the prevalence of certain clinical features of schizophrenia (Tseng et al., 2009). The present study compared NVHL rats to control rats in social interaction observations, locomotor testing with and without amphetamine, measurements of sensorimotor gating, and set-shifting abilities. Unique to the present study is the use of an automated task to show these set shifting deficits in NVHL rats. Additionally, previous research has evaluated error types during set shifting, but never have error types been evaluated in NVHL rats during the automated procedure. Another feature of this study is the use of a rat group pre-exposed to a cue light stimulus, a group non pre-exposed, and a reversal group to evaluate lesion-sham differences in their ability to adapt to rule sets opposite of their side bias. NVHL rats in the present study demonstrated reduced prepulse inhibition, an exaggerated hyperlocomotion effect to amphetamine, and deficits in set-shifting compared to control counterparts. Deficits in set-shifting were only seen in rats that were pre-exposed to a cue light, and not found in those that were not pre-exposed to a cue light or those involved in reversal learning. This study attests to the validity of the NVHL model in reproducing impairment expressions in rats that are analogous to humans with schizophrenia.