Seminars & Events
Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.
Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195.
Friday, October 25, 2013: Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese? It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.
Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.
Jones, Shelby (2012). Cognitive and behavioral impairments evaluated in the neonatal ventral hippocampus lesion rat model of schizophrenia. (Mentor: A.M. Brady)
The neonatal ventral hippocampus lesion is a neurodevelopmental model of schizophrenia that utilizes the disruption of specific anatomical pathways that may be directly related to the prevalence of certain clinical features of schizophrenia (Tseng et al., 2009). The present study compared NVHL rats to control rats in social interaction observations, locomotor testing with and without amphetamine, measurements of sensorimotor gating, and set-shifting abilities. Unique to the present study is the use of an automated task to show these set shifting deficits in NVHL rats. Additionally, previous research has evaluated error types during set shifting, but never have error types been evaluated in NVHL rats during the automated procedure. Another feature of this study is the use of a rat group pre-exposed to a cue light stimulus, a group non pre-exposed, and a reversal group to evaluate lesion-sham differences in their ability to adapt to rule sets opposite of their side bias. NVHL rats in the present study demonstrated reduced prepulse inhibition, an exaggerated hyperlocomotion effect to amphetamine, and deficits in set-shifting compared to control counterparts. Deficits in set-shifting were only seen in rats that were pre-exposed to a cue light, and not found in those that were not pre-exposed to a cue light or those involved in reversal learning. This study attests to the validity of the NVHL model in reproducing impairment expressions in rats that are analogous to humans with schizophrenia.