Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Ehrig, William (2012). Effect of prenatal fluoxetine exposure and neonatal tactile stimulation on motor and cognitive behavior in adult rats. (Mentor: A. Bailey)
Fluoxetine (Prozac), a selective serotonin re-uptake inhibitor (SSRI), is commonly prescribed for the treatment of depression during pregnancy. Although the long-term effects of prenatal fluoxetine exposure are not clear, rat models of prenatal fluoxetine exposure have found increased anxiety-like and depressive-like symptoms, along with contrasting evidence on motor and cognitive effects in adult offspring following prenatal fluoxetine exposure. Prenatal fluoxetine exposure has been associated with altered synaptogenesis and dendritic complexity in the pyramidal neurons of the frontal cortex. Tactile stimulation has been shown as an effective tool for morphological and behavioral recovery following early damage to the frontal cortex. Following oral administration of prenatal fluoxetine (10mg/kg/day) or vehicle treatment to pregnant mothers from GD0-PD7, offspring were split into stimulated and non-stimulated groups to receive tactile stimulation three times daily for 15-minute periods from PD3-21. Offspring were measured for their performance on the rota-rod, novel object recognition and reversal learning tasks after PD90. A near significant effect of drug condition showed a trend towards a decrease in both latency and final RPM for prenatal fluoxetine exposed female rats. Significant increases in perseverative errors were seen in prenatal exposed female rats during the initial reversal session. Significant decreases in learning errors were seen in female rats that received tactile stimulation. This study supported the hypothesis of sex-dependent long-term detrimental effects of prenatal fluoxetine exposure on behavioral flexibility and motor development. No interaction was seen between prenatal fluoxetine exposure and neonatal tactile stimulation in either rota-rod or reversal learning tasks.