Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
MacFarland, M. (2006). Sex Differences in the Effects of Valium on Neuronal Activation and Elevated Plus-Maze Behavior in the Rat.
Mentor: Dr. Anne Marie Brady
Females are diagnosed with anxiety disorders more frequently than males; however, the majority of animal and preclinical drug research is done with only male subjects. This study aimed to replicate and extend previous research, which has found evidence for sex differences, by examining sex differences and the effects of chronic diazepam (DZ) treatment on behavior in the elevated plus-maze and neuronal activation as assessed by Fos expression in the medial prefrontal cortex (mPFC) and the medial nucleus of the amygdala (MeA). Behavioral results supported the anxiolytic properties of DZ; however, did not illustrate sex differences. Maze-evoked Fos results found evidence for laterality, as well a DZ influenced decrease in activation, in both regions. Sex was found to interact with laterality in the MeA. Increased Fos expression was seen in the MeA in females when compared to males. It is possible that the activation is due to the anxiety-inducing event more than the animal’s response to that event since no significant sex differences were seen in the behavior in the elevated plus-maze. The current study supports and expands previous research regarding drug effects in the elevated plus-maze and maze-evoked Fos expression, however, does not support findings of sex differences in elevated plus-maze behavior.
Read the paper (pdf format, 286KB)