Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Konka, K.G., and Bailey, A.M. (2010, November). Investigation of the effects of pup postnatal exposure to fluoxetine on adult rat emotional and motor behavior.
Poster presented at the Society for Neuroscience Annual Meeting, San Diego, CA.
Women diagnosed with post-partum depression are often treated with selective serotonin reuptake inhibitors (SSRI). SSRIs can readily pass through the mother’s breast milk to the infant during breast feeding. We aimed here to examine the long-term neurobehavioral and developmental effects of SSRI exposure to infants during lactation. In the present study, dams were given 12 mg/kg of fluoxetine per day in crushed food pellets. Male rat pups were exposed to fluoxetine through dam’s milk from post-natal day (PD) 8 to PD 21. Rats were allowed to mature undisturbed until adulthood ( > PD65) when they underwent behavioral and emotional testing. Fluoxetine exposed rats spent significantly less time in the closed arms of an elevated plus maze than control rats. Fluoxetine-exposed rats did not show differences in a novel open field or in a forced swim test when compared to control animals. However, rats exposed to fluoxetine had a significantly lower latency to fall and reached a lower rotation per minute (RPM) than control animals when tested on the rotarod. These results indicate that postnatal exposure to fluoxetine may have long-term emotional and motor side effects that should be considered.