Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Chiappelli, J. (2004, May). Behavioral Functions of 5-HT1A Receptors in Rat Orbitofrontal Cortex.
Mentor: Dr. Aileen Bailey
Cannula were implanted in the orbitofrontal cortex (OFC), a prefrontal region of the brain, of 17 rats. The behavior of these animals was observed after intracerebral infusion or intraperitoneal injection of 8-OH-DPAT, a serotonin- 1A agonist. Behavior paradigms used were the open field, social interaction, forced swim and prepulse inhibition tests. Intracerebral infusion of 8-OH-DPAT increased exploratory behavior, had a weak anxiety-reducing effect, and decreased social interaction of the rats, but did not affect depression like behavior or sensorimotor gating. Systemic injection of 8-OH-DPAT had an antidepressant-like effect. Results indicate a role of 5-HT1A receptors in the OFC in regulating social and emotional behaviors, and may have implications for psychopathology.
Read the paper (pdf format, 1.71 MB)