Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Ivy, David (2007). Oxidant Stress and Nicotine’s Role in Diffuse Vascular Injury.
Dr. Anne Marie Brady
The present study investigated nicotine’s role in oxidative stress and the pathogenesis of atherosclerosis in the cerebrovasculature of rats. Specifically, endothelial nitric oxide synthase (eNOS), superoxide dismutase (SOD), and nitrotyrosine levels were examined in endothelial cells (ECs) of the basilar artery to investigate the role of reactive oxygen species (ROS) in oxidative stress while proliferating cell nuclear antigen (PCNA) was examined in vascular smooth muscle cells (VSMCs) to investigate nicotine-induced promotion of atherosclerosis. This report found that nitrotyrosine levels were elevated in rats treated with nicotine and given a withdrawal period of 7 days while PCNA levels were elevated in rats treated with nicotine for 28 days. Discussed are the implications of these findings and the compensatory mechanisms of the vascular system involved in the cessation of smoking/nicotinic intake.