Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Graydon, Megan (2009). Examining anxiety and depression in a rat model of Alzheimer’s disease. (Mentor: A. Bailey)
Alzheimer’s Disease (AD) is a neurodegenerative disease that affects the cognitive functioning of humans (Hollingwoth et al., 2006). Damage to the nBM via human AD or an experimental lesion may alter processing in the amygdala leading to changes in emotion and mood. AD has also been shown to affect mood, such as anxiety and depression in humans (Delano- Wood et al., 2007). The nBM is known to send cholinergic projections to the amygdala (Mesulam et al., 1983), which has been previously shown to be involved in aspects of emotional learning and fear responding (LeDoux, 2000). The researchers hypothesized that quisqualic acid lesions will disrupt the cholinergic pathways from the nBM to the amygdala, which will cause an increase in time spent immobile in the forced swim test, decrease in preference for sucrose in the sucrose preference test and decrease in entries and time spent in the open arms in the elevated plus maze. 192- IgG saporin nBM lesions were hypothesized to effect projections to the cortex and will have fewer changes seen in depression and anxiety- like behaviors of the rats. The researchers found that there was so significant difference in anxiety and depressive-like behaviors seen in rats with nBM lesions and sham control rats. The data however suggests a trend that may support the current hypotheses if repeated.