Seminars & Events

Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.

Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195

Friday, October 25, 2013:  Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese?  It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.

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Alumni Highlight

Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.

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SMP Spotlight

Katie Gluskin and Jeff Haus present their SMP
Katie Gluskin and Jeff Haus, "Entorhinal Cortex Lesions, Habituation, and Latent Inhibition," 2013. Gluskin and Haus, the 2013 co-winners of the Neuroscience Award, infused a neurotoxin into the entorhinal cortex of rats to induce a lesion, and measured the resulting habituation and latent inhibition behavior within a fear conditioning paradigm.

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Graydon, Megan (2009).  Examining anxiety and depression in a rat model of Alzheimer’s disease. (Mentor: A. Bailey)

Abstract 

Alzheimer’s Disease (AD) is a neurodegenerative disease that affects the cognitive functioning of humans (Hollingwoth et al., 2006). Damage to the nBM via human AD or an experimental lesion may alter processing in the amygdala leading to changes in emotion and mood. AD has also been shown to affect mood, such as anxiety and depression in humans (Delano- Wood et al., 2007). The nBM is known to send cholinergic projections to the amygdala (Mesulam et al., 1983), which has been previously shown to be involved in aspects of emotional learning and fear responding  (LeDoux, 2000). The researchers hypothesized that quisqualic acid lesions will disrupt the cholinergic pathways from the nBM to the amygdala, which will cause an increase in time spent immobile in the forced swim test, decrease in preference for sucrose in the sucrose preference test and decrease in entries and time spent in the open arms in the elevated plus maze. 192- IgG saporin nBM lesions were hypothesized to effect projections to the cortex and will have fewer changes seen in depression and anxiety- like behaviors of the rats. The researchers found that there was so significant difference in anxiety and depressive-like behaviors seen in rats with nBM lesions and sham control rats. The data however suggests a trend that may support the current hypotheses if repeated.