Seminars & Events

Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.

Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195

Friday, December 5, 2014:  Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.


Alumni Highlight

Check out Jordan Gaines Lewis '11's award-winning blog, Gaines on Brains.




SMP Spotlight

Katie Gluskin and Jeff Haus present their SMP
Katie Gluskin and Jeff Haus, "Entorhinal Cortex Lesions, Habituation, and Latent Inhibition," 2013. Gluskin and Haus, the 2013 co-winners of the Neuroscience Award, infused a neurotoxin into the entorhinal cortex of rats to induce a lesion, and measured the resulting habituation and latent inhibition behavior within a fear conditioning paradigm.


Flerlage, Jesse (2011).  Role of delta FosB in enhanced incubation of cocaine craving in the neonatal ventral hippocampal lesion model of schizophrenia. (Mentor: A.M. Brady)


Schizophrenia patients are 5 times more likely to develop substance use disorder (SUD) than the general population, with nearly half of patients developing some form of SUD during their lifetime. The primary addiction hypothesis proposes that the increased prevalence of SUD in schizophrenia populations is that addictive behavior is a primary symptom of the disorder stemming from overlapping neuropathology. The neonatal ventral hippocampal lesion model of schizophrenia in rat produces a variety of schizophrenia-like anomalies in behavior including aspects of enhanced self-administration of drugs of abuse. To further investigate cocaine-regulated behavior in the NVHL the incubation of cocaine craving paradigm was applied. Animals received either NVHL or SHAM lesions postnatal 6-8 days. Upon reaching adulthood animals began 10 days of 6hr/day sessions FR1 self-administration of cocaine training. Active lever responding resulted in .75 mg/kg cocaine infusion over 3.5s in conjunction with a 5s tone/light cue above active lever, followed by a 20s timeout period between infusions. On day 1 and day 30 cue-induced cocaine-seeking behavior was assessed by responding on the formerly active lever in absence of cocaine reinforcement, but the presence of cocaine-paired light-tone cue. Results indicate that both groups significantly increased their cocaine intake across the 10 sessions and NVHL animals acquired self-administration behavior at a similar rate and ingested similar amounts of cocaine during the training phase. Withdrawal responding was only found to significantly increase in a time-dependent manner among NVHL animals, meaning the typical time-dependent increase in responding expected in SHAM animals was not observed, while all other differences were insignificant.