Seminars & Events
Thursday, September 11, 2014: Dr. Bevil Conway (Wellesley College) will speak on his research in visual neuroscience and color at 4:30 pm in Goodpaster Hall 195.
Monday, October 27, 2014: Dr. Todd Gould (University of Maryland Baltimore) will speak on "Genes to behaviors to treatments in bipolar disorder" at 4:45 pm in Goodpaster Hall 195.Friday, December 5, 2014: Dr. Brian Mathur (University of Maryland Baltimore) will speak on "Braking bad: Aberrant inhibitory neurotransmission in addiction" at 3:00 pm in Goodpaster Hall 195.
Cole, Trey (2010). The Effects of Adolescent Stress on Adult Working Memory and Susceptibility to Drug Addiction in a Neurodevelopmental Animal Model of Schizophrenia. Mentor: Dr. Anne Marie Brady
Schizophrenic patients experience significant amounts of stress during their daily lives. Also, schizophrenics suffer from impaired working memory and increased rates of drug addiction. Chronic stress produces similar effects. A current neurodevelopmental animal model of schizophrenia involves neonatal ventral hippocampus excitotoxic lesions (NVHL), which produce an array of schizophrenic-like symptoms in adulthood. The current study investigated the effects of the NVHL and 6-hr daily restraint stress for 3 wks during adolescence on working memory in the novel object recognition test and drug-seeking behaviors in the conditioned place preference test. Results showed that restraint stress impaired working memory performance, but the NVHL did not. Neither variables affected conditioned-place preference performance. NVHL + restraint combined to increase locomotor activity in the conditioned place preference task. Possible explanations for the non-effects of NVHL are discussed. Implications include the need to reduce adolescent stress, especially when there is evidence of early insult to the hippocampus.