Seminars & Events

Friday, October 4, 2013: Dr. Laurie Ryan, SMCM '86 (National Institute on Aging) will speak on "Alzheimer's Disease: Targets and Treatments" at 3:00 pm in Goodpaster Hall 195.

Monday, October 21, 2013: Dr. Greg Elmer (University of Maryland Baltimore) will speak on "Domains and Constructs in Motivation: Where Does the Habenula Fit In?" at 4:45 pm in Goodpaster Hall 195

Friday, October 25, 2013:  Dr. Terry Davidson (American University) will speak on "Why We Overeat and Become Obese?  It Could be What We Think!" at 3:00 pm in Goodpaster Hall 195.

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Alumni Highlight

Dr. Gwen Calhoon '06 recently received her Ph.D. in Neuroscience from the University of Maryland Baltimore, and was inducted into Nu Rho Psi.

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SMP Spotlight

Katie Gluskin and Jeff Haus present their SMP
Katie Gluskin and Jeff Haus, "Entorhinal Cortex Lesions, Habituation, and Latent Inhibition," 2013. Gluskin and Haus, the 2013 co-winners of the Neuroscience Award, infused a neurotoxin into the entorhinal cortex of rats to induce a lesion, and measured the resulting habituation and latent inhibition behavior within a fear conditioning paradigm.

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Blackwell, Robert (2008).  Cognitive Deficits in Beta-Catenin Knockout Mice: An Endophenotype Approach to Modeling Bipolar Disorder
Mentor: Dr. Anne Marie Brady

Abstract 

Lithium is currently the only novel pharmacological treatment for bipolar disorder.  Developing novel medications is inhibited by the lack of a valid animal model for bipolar disorder.  At therapeutic concentrations, lithium inhibits GSK-3, disinhibiting beta-catenin.  Beta-catenin overexpression decreases immobility in the forced swim test (correlated with depressive behavior) and amphetamine induced hyperlocomotion (correlated with manic behavior), suggesting beta-catenin is involved in the pathophysiology of bipolar disorder.  A progressive beta-catenin knockout increased immobility time in the tail suspension test, but had no effect on immobility time in the forced swim test or hyperactivity, in male mice.  The present study attempted to determine the validity of the progressive beta-catenin knockout model in female mice.  Subjects had increased immobility time in the tail suspension test, but there was no effect of knockout on the forced swim test, baseline activity, or spatial working memory.